Lessons from the Treblinka Archive: Transnational Collections and their Implications for Historical Research

In work for his 1979 book The Death Camp Treblinka, Alexander Donat began the process of locating survivors of the camp and recording their histories. In a telling testament to the lethality of this place, he could identify only sixty-eight survivors. Analysis of Donat’s early findings—emerging six years prior to the publication of any major academic monograph on the subject—offers a window into the difficulties of conducting research on this Nazi extermination camp and its widely-scattered witnesses. Treblinka’s disembarkation ramp was effectively the eye of a transnational needle through which so many passed and so few emerged. Victims of this camp arrived from at least ten European states, while its survivors fled or immigrated to at least as many countries during and after the war. The origins of these people, their later movements, and the international justice process in the years after World War II created a paper trail that forms the nucleus of the Treblinka archive. From the late-1970s until the death of Treblinka’s last known survivor, Samuel Willenberg, in 2016, historians, museum professionals, and others have conducted interviews and drafted works that added to this body of sources. As a tragedy of human criminality that disregarded international borders, Treblinka requires wide-ranging research to reconstruct its history. This paper enters ongoing discussions about the difficulties and importance of transnational historical research as it highlights the birth of the far-flung Treblinka archive and poses questions about the skills, resources, and tools required to do such work. The commentary and suggestions presented here have meaning not only for the history of Treblinka, but also for the process of doing cross-border historical research more generally

Stability of Beams, Plates and Membranes due to Subsonic Aerodynamic Flows and Solar Radiation Pressure

<p>This dissertation explores the stability of beams, plates and membranes due to subsonic aerodynamic flows or solar radiation forces. Beams, plates and membranes are simple structures that may act as building blocks for more complex systems. In this dissertation we explore the stability of these simple structures so that one can predict instabilities in more complex structures. The theoretical models include both linear and nonlinear energy based models for the structural dynamics of the featureless rectangular structures. The structural models are coupled to a vortex lattice model for subsonic fluid flows or an optical reflection model for solar radiation forces. Combinations of these theoretical models are used to analyze the dynamics and stability of aeroelastic and solarelastic systems. The dissertation contains aeroelastic analysis of a cantilevered beam and a plate / membrane system with multiple boundary conditions. The dissertation includes analysis of the transition from flag-like to wing-like flutter for a cantilevered beam and experiments to quantify the post flutter fluid and structure response of the flapping flag. For the plate / membrane analysis, we show that the boundary conditions in the flow direction determine the type of instability for the system while the complete set of boundary conditions is required to accurately predict the flutter velocity and frequency. The dissertation also contains analysis of solarelastic stability of membranes for solar sail applications. For a fully restrained membrane we show that a flutter instability is possible, however the post flutter response amplitude is small. The dissertation also includes analysis of a membrane hanging in gravity. This systems is an analog to a spinning solar sail and is used to validate the structural dynamics of thin membranes on earth. A linear beam structural model is able to accurately capture the natural frequencies and mode shapes. Finally, the dissertation explores the stability of a spinning membrane. The analysis shows that a nonlinear model is needed to produce a conservative estimate of the stability boundary.</p>Dissertatio

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Recent Advances in Heliogyro Solar Sail Structural Dynamics, Stability, and Control Research

Results from recent NASA sponsored research on the structural dynamics, stability, and control characteristics of heliogyro solar sails are summarized. Specific areas under investigation include coupled nonlinear finite element analysis of heliogyro membrane blade with solar radiation pressure effects, system identification of spinning membrane structures, and solarelastic stability analysis of heliogyro solar sails, including stability during blade deployment. Recent results from terrestrial 1-g blade dynamics and control experiments on "rope ladder" membrane blade analogs, and small-scale in vacuo system identification experiments with hanging and spinning high-aspect ratio membranes will also be presented. A low-cost, rideshare payload heliogyro technology demonstration mission concept is used as a mission context for these heliogyro structural dynamics and solarelasticity investigations, and is also described. Blade torsional dynamic response and control are also shown to be significantly improved through the use of edge stiffening structural features or inclusion of modest tip masses to increase centrifugal stiffening of the blade structure. An output-only system identification procedure suitable for on-orbit blade dynamics investigations is also developed and validated using ground tests of spinning sub-scale heliogyro blade models. Overall, analytical and experimental investigations to date indicate no intractable stability or control issues for the heliogyro solar sail concept

Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation

The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically heterogenous tumors. To evaluate the molecular features of these tumors, 98 ampullary adenocarcinomas were evaluated and compared to 44 distal bile duct and 18 duodenal adenocarcinomas. Genomic analyses revealed mutations in the WNT signaling pathway among half of the patients and in all three adenocarcinomas irrespective of their origin and histological morphology. These tumors were characterized by a high frequency of inactivating mutations of ELF3, a high rate of microsatellite instability, and common focal deletions and amplifications, suggesting common attributes in the molecular pathogenesis are at play in these tumors. The high frequency of WNT pathway activating mutation, coupled with small-molecule inhibitors of β-catenin in clinical trials, suggests future treatment decisions for these patients may be guided by genomic analysis

Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma

The Cancer Genome Atlas (TCGA) Network recently comprehensively catalogued the molecular aberrations in 487 high-grade serous ovarian cancers, with much remaining to be elucidated regarding the microRNAs (miRNAs). Here, using TCGA ovarian data, we surveyed the miRNAs, in the context of their predicted gene targets.Integration of miRNA and gene patterns yielded evidence that proximal pairs of miRNAs are processed from polycistronic primary transcripts, and that intronic miRNAs and their host gene mRNAs derive from common transcripts. Patterns of miRNA expression revealed multiple tumor subtypes and a set of 34 miRNAs predictive of overall patient survival. In a global analysis, miRNA:mRNA pairs anti-correlated in expression across tumors showed a higher frequency of in silico predicted target sites in the mRNA 3'-untranslated region (with less frequency observed for coding sequence and 5'-untranslated regions). The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes (including DNMT3A and DNMT3B) and substantially decreased ovarian cancer cell viability.This study establishes miRNAs as having a widespread impact on gene expression programs in ovarian cancer, further strengthening our understanding of miRNA biology as it applies to human cancer. As with gene transcripts, miRNAs exhibit high diversity reflecting the genomic heterogeneity within a clinically homogeneous disease population. Putative miRNA:mRNA interactions, as identified using integrative analysis, can be validated. TCGA data are a valuable resource for the identification of novel tumor suppressive miRNAs in ovarian as well as other cancers

Heliogyro Solar Sail Research at NASA

The recent successful flight of the JAXA IKAROS solar sail has renewed interest within NASA in spinning solar sail concepts for high-performance solar sailing. The heliogyro solar sail, in particular, is being re-examined as a potential game-changing architecture for future solar sailing missions. In this paper, we present an overview of ongoing heliogyro technology development and feasibility assessment activities within NASA. In particular, a small-scale heliogyro solar sail technology demonstration concept will be described. We will also discuss ongoing analytical and experimental heliogyro structural dynamics and controls investigations and provide an outline of future heliogyro development work directed toward enabling a low cost heliogyro technology demonstration mission ca. 2020

Team-based learning in pharmacy: The faculty experience

yesAim To assess faculty perceptions and experiences when implementing team-based learning (TBL) across a pharmacy curriculum. Study design A total of 19 faculty members participated in a series of individual semi-structured interviews that allowed freedom of discussion within a structured framework of inquiry. Data were transcribed, coded using NVivo, and analyzed to establish common themes. Participant quotations were chosen to reinforce the themes and give a voice to the participants. Findings and discussion The benefits of TBL were perceived to be enhanced student engagement, peer learning, increased faculty enjoyment of teaching, and student development of transferable skills. Challenges included increased initial workload, writing effective application exercises, and facilitating learner-centered classes. TBL may be useful in optimizing course content to ensure outcomes and activities focus on important concepts. Peer learning appears to benefit student learning. TBL may help equip students with valuable transferable skills. TBL requires an initial upfront investment in faculty development and time to prepare resources. A student-centered approach to learning may be daunting for faculty and require new skill sets. Conclusions Faculty described their support for TBL concluding that the pedagogical benefits of engaging students in active learning, the development of transferable skills for the workplace, and the personal satisfaction felt after a TBL class, outweigh the initial challenges of transitioning to TBL

International consensus on (ICON) anaphylaxis

ICON: Anaphylaxis provides a unique perspective on the principal evidence-based anaphylaxis guidelines developed and published independently from 2010 through 2014 by four allergy/immunology organizations. These guidelines concur with regard to the clinical features that indicate a likely diagnosis of anaphylaxis -- a life-threatening generalized or systemic allergic or hypersensitivity reaction. They also concur about prompt initial treatment with intramuscular injection of epinephrine (adrenaline) in the mid-outer thigh, positioning the patient supine (semi-reclining if dyspneic or vomiting), calling for help, and when indicated, providing supplemental oxygen, intravenous fluid resuscitation and cardiopulmonary resuscitation, along with concomitant monitoring of vital signs and oxygenation. Additionally, they concur that H1-antihistamines, H2-antihistamines, and glucocorticoids are not initial medications of choice. For self-management of patients at risk of anaphylaxis in community settings, they recommend carrying epinephrine auto-injectors and personalized emergency action plans, as well as follow-up with a physician (ideally an allergy/immunology specialist) to help prevent anaphylaxis recurrences. ICON: Anaphylaxis describes unmet needs in anaphylaxis, noting that although epinephrine in 1 mg/mL ampules is available worldwide, other essentials, including supplemental oxygen, intravenous fluid resuscitation, and epinephrine auto-injectors are not universally available. ICON: Anaphylaxis proposes a comprehensive international research agenda that calls for additional prospective studies of anaphylaxis epidemiology, patient risk factors and co-factors, triggers, clinical criteria for diagnosis, randomized controlled trials of therapeutic interventions, and measures to prevent anaphylaxis recurrences. It also calls for facilitation of global collaborations in anaphylaxis research. In addition to confirming the alignment of major anaphylaxis guidelines, ICON: Anaphylaxis adds value by including summary tables and citing 130 key references. It is published as an information resource about anaphylaxis for worldwide use by healthcare professionals, academics, policy-makers, patients, caregivers, and the public